Formulation and evaluation of biodegradable microsphere of plant extract of “pongamia pinnata”

Abstract

The present study focuses on the formulation and evaluation of biodegradable microspheres containing plant extract of Pongamia pinnata (Karanja) for their antimicrobial activity. Pongamia pinnata, a plant renowned for its medicinal properties, was chosen for its bioactive compounds with potential therapeutic benefits. The primary objective was to develop a delivery system that enhances the stability and efficacy of the plant extract while ensuring controlled release and biodegradability. Microspheres were formulated using a solvent evaporation technique, employing biodegradable polymers such as HPMC and EC. The Pongamia pinnata extract was meticulously incorporated into the polymer matrix to form microspheres. Various parameters such as particle size, encapsulation efficiency, and surface morphology were characterized using scanning electron microscopy (SEM). The antimicrobial activity of the formulated microspheres was evaluated against common pathogenic microorganisms including Escherichia coli using the well diffusion method. The results demonstrated significant antimicrobial activity, indicating that the encapsulated extract retained its bioactivity and was effectively released from the microspheres. The study concluded that the biodegradable microspheres of Pongamia pinnata extract not only provide a sustained release of the bioactive compounds but also enhance the antimicrobial efficacy. This innovative approach holds promise for developing effective and eco-friendly antimicrobial agents, paving the way for further research in the domain of plant-based therapeutics.

Keywords

Biodegradable Microspheres, Pongamia Pinnata, Antimicrobial Activity, Solvent Evaporation Technique, Plant-Based Therapeutics