Abstract

The present study was designed to perform evaluate the antidepressant activity of the ethanolic extract of cassia fistula leaf. The leaf of cassia fistula was extracted using ethanol as solvent by soxhlet apparatus. The evaluation of antidepressant activity was done using a tail suspension test, and locomotor activity-induced antidepressant models in wistar albino rats. The work entitled Evaluation of Anti-depression Activity of the leaf of Cassia Fistula was to determine the efficacy and safety in experimental animals. Both aqueous and alcoholic extracts of the leaf of cassia fistula (linn.) have shown a significant reduction in the depression of CNS as compared to tail suspension animals and locomotor activity confirming their anti-depression property. The aqueous and alcoholic extract of the leaf of cassia fistula (linn.) has shown a significant decrease in brain serotonin levels, an increase in norepinephrine levels.

Keywords

• Anti-Depression,
• Cassia Fistula,
• Serotonin,
• Norepinephrine,
• Alcoholic Extract

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